Hyaluronidase/Pertuzumab/Trastuzumab Injection (PERTUZUMAB/TRASTUZUMAB/HYALURONIDASE - SUBCUTANEOUS INJECTION)

For treating cancer.

Brand Name(s): Phesgo

Generic Name: Hyaluronidase/Pertuzumab/Trastuzumab-zzxf

Instructions

This medicine is given as an injection into the skin.

This medicine should be given by a trained health care provider.

You must be monitored by a health care professional during and after each dose is given.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Your doctor may prescribe other medications to reduce side effects. Follow instructions carefully.

Keep using this medicine for the full number of days that it is prescribed. Do not stop the medicine even if you start to feel better.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

May cause mouth sores. Brush teeth gently. Avoid products containing alcohol. Rinse mouth with a mixture of water and baking soda or salt.

Some patients with weak hearts may have worsening of symptoms. If you notice difficulty breathing, weight gain, or swelling of your legs or ankles, let your doctor know right away.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

This medicine may cause dizziness or fainting. Do not stand or sit up quickly.

Your ability to stay alert or to react quickly may be impaired by this medicine. Do not drive or operate machinery until you know how this medicine will affect you.

If possible, avoid using with alcohol, marijuana, or other medicines that can cause dizziness or drowsiness. These include allergy/cold products, muscle relaxers, sleep aids, and pain relievers.

This medicine may reduce your body's ability to fight infections. Avoid contact with people with colds, flu or other infections. Contact your doctor if you develop fever, cough, sore throat, or chills.

Speak with your health care provider before receiving any vaccinations.

Do not breastfeed while on this medicine. You may safely start breastfeeding 7 months after stopping treatment.

This medicine can hurt a new baby in the womb. If you become pregnant while on this medicine, tell your doctor immediately. Your doctor may switch you to a different medicine.

Women of childbearing age should have a negative pregnancy test before starting this medicine.

Women must use reliable forms of birth control while taking this medicine and for 7 months after stopping to prevent pregnancy.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

  • agitated feeling or trouble sleeping
  • decreased appetite
  • back pain
  • constipation
  • dizziness
  • lack of energy and tiredness
  • hair loss
  • pain, redness, swelling near injection
  • pain in the joints
  • nausea and vomiting
  • stomach upset or abdominal pain
  • changes in taste or unpleasant taste
  • weakness

Call your doctor or get medical help right away if you notice any of these more serious side effects:

  • bone pain
  • wheezing or difficulty breathing
  • unusual bruising or discoloration on skin
  • chest pain
  • changes in memory, mood, or thinking
  • coughing
  • swelling of the legs, feet, and hands
  • fainting
  • feeling of heat or flushing
  • fever or chills
  • numbness or tingling in hands and feet
  • red, burning, or itchy skin
  • unusual or unexplained tiredness or weakness
  • severe or persistent vomiting
  • sudden or unexplained weight gain

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.

Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.